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Updated: Jul 9, 2026

A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
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A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects

Published on: August 14, 2013

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科巴尔特毒性诱导小鼠视网膜病变和视神经病变

Basel Obied1,2, Stephen Richard1,3, Alon Zahavi4,5,6

  • 1The Krieger Eye Research Laboratory, Bruce and Ruth Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

Investigative ophthalmology & visual science
|November 27, 2024
PubMed
概括

在小鼠中,的毒性导致视力问题和视网膜炎症. 这项研究强调了暴露对视觉系统的影响,影响视网膜功能并导致细胞变化.

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In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

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Author Spotlight: Advancements in In Vivo and Ex Vivo Retinal Imaging for Improved Glaucoma Diagnosis and Treatment

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...