环酸阿维拉林D-O具有抗疟疾活性,来自马里亚纳海峡海 - - 来自Hamigera ingelheimensisMSC5
Hao Li1,2, Yuling Chen1, Bingqing Tang1,2
1State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.
Journal of natural products
|November 27, 2024
概括
研究人员从深海真菌中发现了12种新的循环五,avellanins D-O. 一种化合物显示出强大的抗疟疾活性,突出了药物发现的海洋天然产品.
科学领域:
- 海洋天然产品化学 海洋天然产品化学
- 微生物的二次代谢.
- 从极端环境中发现药物的发现.
背景情况:
- 极端的海洋环境,如马里亚纳海沟,是新型自然产品的来源.
- ,如来自深海海的*Hamigera ingelheimensis*MSC5,是有希望的生物活性化合物的生产者.
- 了解生物合成途径对于发现和生产新的天然产品至关重要.
研究的目的:
- 来自马里亚纳海峡沟衍生的真菌*Hamigera ingelheimensis*MSC5.5.的新化合物的发现和特征.
- 阐明孤立化合物的结构和绝对配置.
- 调查发现的自然产品的潜在生物活性.
主要方法:
- 生物合成基因集群分析.
- 综合的代谢策略,包括MALDI-TOFMS,NMR和LC-MS/MS.
- 全球天然产品社会分子网络 (GNPS) 用于化合物识别.
- 射线衍射分析和马菲的方法用于结构阐明.
主要成果:
- 分离了12种新的循环五,阿维拉宁D-O (1-12) 和一种已知的化合物,阿维拉宁C (13).
- 结构和绝对配置得到了充分阐明.
- 化合物6显示出强大的抗疟疾活性,IC50值为0.19±0.09μM.
- 提出了一个可信的生物合成途径为avellanins.
结论:
- 这项研究成功地从深海真菌中识别出新的循环五.
- 这些发现强调了来自极端环境的海洋微生物作为新药潜在来源的潜力.
- 化合物6是作为抗疟疾药物进一步开发的有希望的候选物.
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