肝脏纤维化负担跨越了甲状腺功能低下症的频谱
Tingting Du1,2, Yuchai Huang3, Yongman Lv4,5
1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Journal of gastroenterology
|November 27, 2024
概括
肝脏纤维化负担在甲状腺功能低下症中很常见,随着严重程度的增加而增加. 建议对所有患有甲状腺功能低下的患者进行肝纤维化查,即使是甲状腺功能正常低下的患者.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 关于整个甲状腺功能低下谱的肝纤维化负担的数据有限.
- 甲状腺功能低下症对肝纤维化患病率的影响尚未得到充分证实.
研究的目的:
- 为了评估肝脏纤维化负担的患病率,在整个类甲状腺功能低下的个体中.
- 为了确定甲状腺功能和肝纤维化之间的关联.
主要方法:
- 从2019年至2021年对30091个人的横截面分析.
- 基于甲状腺功能的分类:严格正常,低正常,亚临床甲状腺功能低下和明显的甲状腺功能低下.
- 使用振动控制的短暂弹性图 (VCTE) 评估的肝纤维化.
主要成果:
- 与严格正常相比,低正常,亚临床和明显的甲状腺功能低下组观察到肝纤维化 (轻度,显著,晚期,肝硬化) 的患病率增加.
- 过度的甲状腺功能低下症显示肝脏纤维化负担最高.
- 显著和晚期肝纤维化与低正常,亚临床和明显的甲状腺功能低下症有很强的关联.
结论:
- 肝脏纤维化负担在明显的甲状腺功能低下症中非常普遍.
- 纤维化负担在整个甲状腺功能障碍谱中升级,包括低正常的甲状腺功能.
- 建议在患有甲状腺功能低下症的患者进行肝纤维化常规查.
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