在健康的年轻男性中,控制的食酸盐负载会提高血酸盐和FGF23水平
Jennifer Scotti Gerber1,2, Eva Maria Pastor Arroyo3, Johanne Pastor4
1Division of Nephrology, University Hospital Zurich, Zurich, Switzerland.
Pflugers Archiv : European journal of physiology
|November 27, 2024
概括
在健康男性中,高酸盐摄入量会增加血液酸盐水平和24小时酸盐分泌量. 这种升高可能会造成心血管健康风险,因为它与血清酸盐增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 矿物质的新陈代谢.
背景情况:
- 饮食中的无机酸盐 (Pi) 摄入影响脏Pi通过PTH和FGF23等激素排泄.
- 以前对饮食Pi效应的人类研究受限于短时间或多样化的摄入量.
- 在短时间内控制的,孤立的饮食Pi变化的影响仍然不清楚.
研究的目的:
- 为了研究受控的高饮食Pi摄入量对健康年轻男性矿物质代谢的影响.
- 确定孤立的饮食Pi变化对关键荷尔蒙和代谢参数的影响.
主要方法:
- 一个随机交叉试验,涉及10名健康的年轻男性.
- 参与者食用了低Pi饮食 (含酸盐结合剂) 或高Pi饮食 (补充酸盐囊) 每天5天,有7天的洗期.
- 测量包括血Pi,尿Pi和,完整的FGF23 (iFGF23),以及其他激素标记.
主要成果:
- 高Pi摄入量显著增加了血Pi水平和24小时的尿Pi排泄.
- 尿路分泌量减少,而血IFGF23增加,血Klotho减少.
- 在PTH,卡尔西迪奥尔,卡尔西醇,Fetuin-A,多巴胺或阿尔多斯特水平上没有观察到显著的变化.
结论:
- 在健康的年轻男性中,饮食中增加的Pi摄入量会增加血Pi和脏Pi分泌量.
- 激素iFGF23在饮食中摄入大量的Pi时,在Pi平衡和酸醇减少中发挥作用.
- 持续高Pi摄入可能代表心血管健康风险,由于血清Pi水平升高.
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