杆菌感染是儿童非酒精性脂肪肝疾病的危险因素吗?
Sana Barakat1, Mohamed Abdel-Fadeel1, Ola Sharaki2
1Paediatric Department, Faculty of Medicine, Alexandria University, Champollion Street El-Khartoum Square, Azarita Medical Campus 21311, Alexandria, Egypt.
European journal of pediatrics
|November 27, 2024
概括
杆菌感染与儿童患非酒精性脂肪肝疾病 (NAFLD) 的风险更高有关. 这种细菌感染,特别是Cag A菌株,与NAFLD严重程度和等级的增加有关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 在儿童中越来越普遍,与儿童肥胖率的上升有关.
- 胰岛素抵抗和脂质失调是NAFLD发展的关键因素,通常由肠肝轴解释.
- 杆菌 (H. pylori) 感染正在研究其在儿科NAFLD中的潜在作用.
研究的目的:
- 调查H. pylori感染与儿童NAFLD之间的关联.
- 为了确定H. pylori感染和NAFLD等级之间的关系.
- 确定NAFLD的预测因子和影响其在儿科病例中的等级的因素.
主要方法:
- 一项病例控制研究涉及100名患有NAFLD的儿童和100名对照人群,所有这些儿童都被评估H. pylori便抗原.
- 在感染个体中检测H. pylori特异性抗体 (Cag A,Vac A,Gro EL,HCPC,Ure A) 的血清分析.
- 回归分析以确定NAFLD的预测因素和与NAFLD等级相关的因素.
主要成果:
- 与对照组 (25%) 相比,NAFLD (64%) 的儿童中H. pylori感染的发生率明显高.
- 在NAFLD儿童中,H. pylori Cag A和Vac A阳性比较高.
- H. pylori阳性 (OR=5.02),Homa IR (OR=18.84),腰部百分位 (OR=1.18) 和甘油三 (OR=1.03) 预测了NAFLD.
- Cag A阳性与较高的NAFLD等级 (2级) 有关.
结论:
- 杆菌感染可能会增加儿童患NAFLD的风险.
- H. pylori 感染,特别是 Cag A 菌株感染,与更严重的 NAFLD 有关.
- 甘油三,腰围和Homa IR是儿科NAFLD的独立预测因素.
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