与非冠军相比,奥运冠军的表观遗传衰老减缓
Zsolt Radák1,2,3,4, Dóra Aczél5, Iván Fejes6,7
1Hungarian University of Sport Science, Budapest, Hungary. radak.zsolt@tf.hu.
GeroScience
|November 27, 2024
概括
奥林匹克冠军表现出较慢的表观遗传衰老,这表明强烈,终身炼对健康有好处. 这项研究揭示了男性和女性运动员的明显衰老模式,并确定了与运动和衰老相关的关键基因.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 运动科学 运动科学 运动科学
- 老年学是一门学科.
背景情况:
- 身体活跃的个体表现出延缓表观遗传衰老和改善与年龄相关的健康结果.
- 精英运动员从小就保持高度纪律的生活方式,包括严格的训练和营养.
研究的目的:
- 研究极端体力活动强度对奥运冠军对表观遗传衰老的影响.
- 确定奥林匹克水平的培训是否对生物衰老标志物有好处.
主要方法:
- 在59名匈牙利奥运冠军和332名对照者 (包括205名手) 中,使用7个已建立的表观遗传时钟评估了表观遗传衰老.
- 分析了基因促进物甲基化模式,以确定奥运冠军和非冠军之间的差异.
主要成果:
- 与对照组相比,奥运冠军表现出明显较慢的表观遗传衰老.
- 最近获得奖牌的男性冠军的衰老速度较慢,而女性冠军则呈现相反的趋势.
- 摔运动员比体操运动员,围运动员和水球运动员表现出更高的年龄加速. 鉴定了与突触健康,糖化,金属离子转移,力生成 (低甲基化) 和癌症促进 (超甲基化) 相关的基因.
结论:
- 从青春期到成年期的严格,长期的运动积极影响表观遗传衰老.
- 特定的运动学科和最近的竞争成功可能会对衰老轨迹产生不同的影响.
- 奥林匹克冠军的表观遗传修饰与关键的生物功能和疾病途径有关.
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