人类微生物群中的Bifidobacteriaceae多样性来自大规模的全基因组分析
Edoardo Pasolli1, Italia Elisa Mauriello2, Michele Avagliano2
1Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy; Task Force on Microbiome Studies, University of Naples Federico II, 80138 Naples, Italy.
Cell reports
|November 27, 2024
概括
这项研究揭示了人类微生物群中的Bifidobacteriaceae多样性,受年龄,生活方式和地理位置的影响. 益生菌菌株很少在人类中发现,除了Bifidobacterium animalis.
科学领域:
- 微生物组研究的研究.
- 基因组学就是基因组学.
- 人的肠道细菌是人类的肠道细菌.
背景情况:
- 双菌群是关键的肠道共生物.
- 了解它们的多样性和流行率对于微生物组研究至关重要.
研究的目的:
- 调查人类微生物群中的Bifidobacteriaceae的流行率和菌株水平的多样性.
- 为了确定影响它们的丰富和分布的因素.
主要方法:
- 对9528个人类元基因组进行了大规模的全基因组分析.
- 与1,192个孤立基因组的整合.
- 生物遗传学分析和Bifidobacteriaceae物种级基因组组 (SGB) 的功能注释.
主要成果:
- 确定了110种BifidobacteriaceaeSGBs,其中32种在人类中发现.
- 与年龄相关的患病率 (在老年人中减少) 和具有地理模式的西方化生活方式.
- 发现了潜在的亚种,并确定了年龄/地理驱动的模式.
- 在人类中很少检测到益生菌菌株,除了Bifidobacterium animalis.
- 双菌群的丰富性显示出适度的健康状况预测能力.
结论:
- 人类Bifidobacteriaceae表现出由宿主因素塑造的显著的菌株水平多样性.
- 目前的益生菌菌株与人类肠道种群的重叠有限.
- 需要进一步的研究来了解Bifidobacteriaceae多样性的功能作用和健康影响.
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