大量饮酒但不吸烟预测急性冠状动脉综合征患者的死亡率
Allan Andersen1, Steven R H Beach2, Willem Philibert1
1Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
Epigenetics
|November 27, 2024
概括
过度饮酒 (HAC) 显著增加了冠心病 (CHD) 患者的死亡风险. 然而,吸烟强度与这些患者的冠状动脉阻塞严重程度相反相关.
科学领域:
- 心脏病学 心脏病学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 公共卫生 公共卫生
背景情况:
- 重度饮酒 (HAC) 和吸烟对冠心病 (CHD) 患者死亡率的影响尚不清楚.
- 将这些生活方式因素与不良结果联系在一起的机制需要进一步阐明.
研究的目的:
- 调查慢性HAC (酒精T分数,ATS) 和吸烟强度 (cg05575921甲基化) 的表观遗传生物标志物与全因死亡率和冠状动脉阻塞之间的关联.
- 提高对急性冠状动脉综合征 (ACS) 患者风险因素的理解.
主要方法:
- 对217名患者的分析,这些患者因心脏病相关的ACS而入院.
- 使用的酒精T分数 (ATS) 作为慢性HAC的生物标志物.
- 使用cg05575921甲基化作为吸烟强度的生物标志物.
- 应用考克斯比例危险模型来评估死亡风险和与冠状动脉阻塞的相关性.
主要成果:
- 65%的受试者表现出ATS值,表明慢性HAC.
- 较高的ATS值与所有原因死亡率的增加显著相关 (p < 0.02),最高十分位数的风险增加了2.4倍.
- 相反,cg05575921甲基化与冠状动脉阻塞程度相反相关 (p < 0.003),而ATS则没有.
- 吸烟强度,而不是HAC,与较不严重的冠状动脉阻塞相关.
结论:
- 沉重的酒精消费是CHD患者死亡率的重要,被低估的因素.
- 吸烟强度与ACS患者的冠状动脉阻塞严重程度相反.
- 在心血管疾病患者群体中,物质使用治疗似乎未得到充分利用.
相关概念视频
01:26Stress Prevention and Stress Management Techniques IV
26
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
26
01:27CNS Depressants: Alcohol and Nicotine
174
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
174
01:20Exercise and Cardiovascular Response
737
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
737