在原发性前列腺癌中,免疫抑制性瘤微环境促进瘤免疫逃生
Angelyn Anton1, Ryan Hutchinson1, Christopher M Hovens2,3
1Division of personalised oncology, Walter and Eliza Hall Institute, Melbourne, Australia.
PloS one
|November 27, 2024
概括
前列腺癌免疫疗法由于免疫抑制瘤微环境而取得有限的成功. 较高的PD-L1+细胞密度预测生化复发,但整体T细胞活性较低,影响未来的免疫疗法策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 尿瘤学 尿瘤学
背景情况:
- 免疫治疗在前列腺癌中的有效性有限,可能是由于免疫抑制性瘤微环境 (TME).
- 以前的研究表明,前列腺瘤中的PD-L1表达低,免疫细胞透稀少.
- 这项研究进一步描述了原发性前列腺癌中免疫TME的特征.
研究的目的:
- 在原发性前列腺癌中特征免疫TME.
- 为了将免疫子群密度与临床结果相关联,特别是生化复发 (BCR) 和转移性疾病.
- 为了研究瘤等级,T阶段和免疫细胞透之间的关系.
主要方法:
- 分析了两组经过激进前列腺切除术治疗的患者队列,按BCR发育和ISUP等级分层.
- 免疫组织化学 (IHC) 染色用于CD8+,CD4+,FoxP3+,CD20+,CD68+和PD-L1的表达.
- 在瘤和周围瘤区域的免疫细胞子集密度的量化.
- 后勤回归分析以确定BCR和转移的风险因素.
主要成果:
- CD68+细胞是最丰富的免疫细胞.
- PD-L1+和PD-L1/CD8+细胞密度通常较低.
- 高年级组和T阶段是BCR和转移的独立预测因素.
- 周围瘤PD-L1+细胞密度增加独立预测BCR (OR 5.33).
- 高度瘤中较高的CD8+和CD4+细胞密度与BCR或转移无关.
结论:
- 前列腺癌等级组和T阶段是BCR和转移的显著预测因素.
- 较低的PD-L1和PD-L1/CD8+细胞密度表明T细胞对瘤抗原的受体识别受损.
- 了解免疫TME对于开发有效的前列腺癌未来免疫治疗策略至关重要.
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