支持呼吸道上皮质和降低炎症以有效治疗普通感冒症状:一个随机对照试验
Pavel Pugach1, Nazlie Sadeghi-Latefi1
1Applied Biological Laboratories Inc, New York, NY, United States of America.
PloS one
|November 27, 2024
概括
一种新的喉喷雾剂,含有粘膜免疫复合物和酸盐,有效地减少了79%的普通感冒症状,包括喉疼痛. 这种治疗支持呼吸道上皮质,并减少炎症,以更快地缓解症状.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 常见感冒病毒引发喘发作,增加对细菌感染的易感性.
- 与安慰剂相比,大多数非处方药的感冒和咳药物缺乏经过证明的疗效.
- 阿司匹林在整体感冒严重程度上显示出25-30%的适度改善.
研究的目的:
- 评估一种含有粘膜免疫综合体 (MIC) 和酸盐的新型喉喷雾剂,以缓解普通感冒的症状.
- 为了确定这种联合治疗是否增强了阿司匹林的疗效.
- 评估对喉疼痛强度和整体感冒症状严重性的影响.
主要方法:
- 这是一项双盲,随机,安慰剂控制的试验,有157名成年参与者.
- 在两天内自行服用喉喷雾剂 (每小时一次) 和药片 (每四小时一次).
- 治疗包括使用阿司匹林的MIC喷雾,使用冬青油的MIC喷雾,或使用阿司匹林和冬青油的MIC喷雾.
主要成果:
- 喉疼痛强度在36小时后在治疗组中减少了68-75%.
- 整体感冒症状严重程度 (修改后的杰克逊评分) 根据治疗减少了38-69%.
- 与安慰剂相比,所有活性疗法都显著降低了症状严重程度.
结论:
- 支持上呼吸道上皮质和减少炎症是治疗普通感冒症状的有效策略.
- 经过测试的喉喷雾配方显示了缓解感冒症状的巨大潜力.
- 需要进一步研究粘膜免疫复合物和酸盐组合用于呼吸道感染.
相关概念视频
Drugs Used in Lower Respiratory Disorders: Overview
352
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
352
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
232
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
232
Common Respiratory Disorders
310
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
310
Acute Respiratory Failure-V
123
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
123
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
237
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
237
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
218
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
218


