用于在人类皮肤微循环中调解电流诱导的血管扩张的协议的可重复性
Alicia Guigui1,2, Léa Liaigre2, Matthieu Roustit1,2
1Univ. Grenoble Alpes, Inserm U1300 -HP2, CHU Grenoble Alpes, Grenoble, France.
PloS one
|November 27, 2024
概括
对前环素 (PGI2) 途径的电流诱导血管扩张 (CIV) 评估是最可复制的. 将数据表达为最大平原或皮肤血管导电率,可确保可靠的结果.
科学领域:
- 身体生理学 身体生理学
- 血管生物学 血管生物学
- 生物医学工程 生物医学工程
背景情况:
- 电流诱导血管扩张 (CIV) 是评估前环素 (PGI2) 途径的一种方法.
- 不同的CIV协议的可重复性以前没有被评估.
研究的目的:
- 评估用于调解CIV的几个协议的可重现性.
- 确定评估CIV可复制性的最佳方法.
主要方法:
- 十名健康的参与者在七天内进行了四次测试.
- 在小腿和前臂上测试了三个不同的CIV协议.
- 使用主体内变化系数和类内相关系数来评估可重复性.
主要成果:
- 协议A,B和C证明了牛犊和前臂的良好至优良的日间复制性.
- 内部,一天内可重现性不太清楚,内部测试没有改善它.
- 当响应表达为绝对或百分比变化时,观察到不可接受的可重现性;在约10%的评估中没有诱导微血管响应.
结论:
- 在日间测试中,CIV是最可复制的.
- 将数据表达为最大平原 (以 perfusion 单位) 或皮肤血管导电率,以及曲线下的面积,产生了最可重现的结果.
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