针对糖尿病患者的血糖调节器设计基于LQIR驱动的滑动模式控制器,具有自适应性达到法则
1Department of Electrical Engineering, National University of Computer and Emerging Sciences, Lahore, Pakistan.
PloS one
|November 27, 2024
概括
这项研究引入了一种新的混合控制策略,用于I型糖尿病的管理. 它结合了线性-正方形-整体-调节器和滑动模式控制器,以提高血糖调节的准确性和对干扰的稳定性.
科学领域:
- 生物医学工程 生物医学工程
- 控制系统工程 控制系统工程
- 内分泌学 在内分泌学.
背景情况:
- 第一种类型糖尿病损害了胰腺调节血糖 (BG) 的能力.
- 现有的控制策略,如线性四边形整体调节器 (LQIR) 和滑动模式控制器 (SMC),在应对噪音和食中断方面存在局限性,或导致胰岛素输液速率扰乱.
- 需要一种控制策略,将LQIR的最佳性与SMC的稳定性相结合.
研究的目的:
- 开发和评估一种混合的LQIR驱动的SMC战略,以改善I型糖尿病的血糖调节.
- 为了利用LQIR和SMC的好处,同时减轻它们的个人缺点.
- 为了提高BG调节的准确性和干扰排斥能力.
主要方法:
- 制定一种混合控制方法,将血糖LQIR定律与创新的标志功能滑动模式达到定律相结合.
- 集成一个定制的LQIR驱动的滑动表面.
- 通过非线性适应机制来增加SMC达成法律,以最大限度地减少聊天和补偿干扰.
- 控制器参数的离线数值优化.
- 通过定制的 MATLAB 模拟在测量噪音和餐点中断的情况下进行分析.
主要成果:
- 混合控制方案成功地产生了来自LQIR的最佳控制决策,同时保持了SMC对干扰的稳定性.
- 非线性适应机制有效地弥补了外部干扰,并最大限度地减少了聊天.
- 模拟显示,BG调节的准确性得到改善,BG水平从高血糖状态正常化到80 mg/dL.
- 拟议的方法显示了增强的干扰排斥能力.
结论:
- 拟议的混合LQIR驱动的SMC策略提供了一个优越的方法,与独立的LQIR或SMC相比,为I型糖尿病提供BG监管.
- 这种新的控制方法有效地平衡了最佳性和稳定性,解决了糖尿病管理的关键挑战.
- 这些发现支持这种先进的控制策略对I型糖尿病患者的潜在临床应用.
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