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Updated: Jun 6, 2025

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EZH2直接甲基化PARP1并调节其在癌症中的活性

Qingshu Meng1,2, Jiangchuan Shen3, Yanan Ren1

  • 1Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Science advances
|November 27, 2024
PubMed
概括

增强酶同类物2 (EZH2) 的增强剂直接修改了多氨酸二酸盐-核糖) 聚合酶-1 (PARP-1),影响了DNA修复和癌症进展. 准EZH2和PARP-1都显示出协同作用的癌症治疗的前景.

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