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Updated: Jun 6, 2025

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

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在巨细胞中识别VISTA调节器,调解癌细胞存活率

Abdalla M Abdrabou1,2,3, Sharif U Ahmed4, Mengqi Jonathan Fan2

  • 1Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Science advances
|November 27, 2024
PubMed
概括

研究人员确定了AhR和IRAK1的关键调节剂,这些调节剂可以控制巨细胞上V域免疫球蛋白抑制T细胞激活 (VISTA) 的作用. 抑制这些可以促进抗瘤免疫反应,克服对免疫检查点阻塞 (ICB) 癌症疗法的抵抗力.

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