[2型糖尿病中MASLD的预测因素:1年后续研究]
Niels H Wacher1, Rita A Gómez-Díaz1, Adriana L Valdez-González1
1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Unidad de Investigación Médica en Epidemiología Clínica. Ciudad de México, México.
Revista medica del Instituto Mexicano del Seguro Social
|November 27, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在2型糖尿病 (T2D) 中很常见. 高HbA1c和腰围预测MASLD的发生率,这表明查有用.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 初级保健研究研究初级保健研究
背景情况:
- 代谢功能障碍相关的脂肪酸性肝病 (MASLD) 是一种与心脏代谢风险因素相关的肝脏脂肪酸症的拟议术语.
- 2型糖尿病 (T2D) 是与肝病相关的显著心脏代谢风险因素.
研究的目的:
- 在初级保健环境中确定MASLD在T2D患者发病率的预测因素.
- 在一年的随访期内评估MASLD的发展.
主要方法:
- 在墨西哥城对5143名2型糖尿病患者 (诊断后≤15年) 的前性队列研究.
- 数据收集包括人体测量,HbA1c,脂质概况,肝酶 (ALT,AST),以及肝硬化指数 (HSI) 和脂质积累产品 (LAP) 的计算.
- 通过异常的ALT水平来识别MASLD.
主要成果:
- 在基线时,28.2%的患者患有MASLD,HSI和LAP得分较高.
- 诊断时的年龄和T2D的持续时间与MASLD相反相关.
- 增加的体重指数,腰围 (WC) 和HbA1c与MASLD风险成正比. 马斯尔德的几率比为HbA1c的1.86和WC的1.88.
结论:
- HSI,LAP,HbA1c和WC的组合有效地识别T2D患者的MASLD.
- 这些标记物可以帮助在初级保健机构早期发现和管理MASLD.
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