每年两次的莱纳卡巴维尔用于预防男性和性别不同的人的艾滋病毒
Colleen F Kelley1,2, Maribel Acevedo-Quiñones3, Allison L Agwu4
1Hope Clinic of Emory University School of Medicine, Decatur, GA.
The New England journal of medicine
|November 27, 2024
概括
与每日服用药物相比,每年两次注射莱纳卡巴维尔可显著降低不同人群中的艾滋病毒感染率. 这种长效的预防方法为HIV暴露前预防 (PrEP) 提供了新的选择.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 皮下注射莱纳卡帕维尔 (Lenacapavir) 已证明,它对女性的艾滋病毒预防有效.
- 莱纳卡巴维尔在其他人群中的暴露前预防 (PrEP) 的有效性仍然不清楚.
研究的目的:
- 评估每年两次皮下注射莱纳卡巴维尔 (lenacapavir) 预防艾滋病毒的疗效和安全性.
- 为了比较lenacapavir与每日口服的emtricitabine-tenofovir 双醇烟酸 (F/TDF) 的疗效.
主要方法:
- 第三阶段,双盲,随机,主动对照试验.
- 参与者被分为2:1的莱纳卡帕维尔 (每26周一次) 或F/TDF (每天口服).
- 初级分析将lenacapavir组的HIV发病率与背景发病率进行比较;二级分析与F/TDF组进行比较.
主要成果:
- 艾滋病毒发病率为0.10每100人/年与莱纳卡巴维尔相比,每100人/年背景发病率为2.37.
- 与背景和F/TDF (0.93每100人年) 相比,莱纳卡巴维尔的HIV发病率明显较低.
- 没有发现重大安全问题;注射部位反应导致1.2%的莱纳卡巴维尔接受者停止治疗.
结论:
- 每年两次服用莱纳卡帕维尔的艾滋病毒发病率明显低于背景率和F/TDF.
- 莱纳卡帕维尔是HIV PrEP在不同人群中的有效和安全的长效选择.
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