相关实验视频
Updated: Jun 6, 2025

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
减少PCV10剂量表对越南肺炎球菌传播的影响
Lay-Myint Yoshida1, Michiko Toizumi1, Hien Anh Thi Nguyen1
1From the Department of Pediatric Infectious Diseases, Institute of Tropical Medicine (L.-M.Y., M. Toizumi, C.I., M. Takegata), the Department of Global Health, School of Tropical Medicine and Global Health (L.-M.Y., M. Toizumi), and Nagasaki University Graduate School of Biomedical Science (L.-M.Y.), Nagasaki University, Nagasaki, and the National Institute of Infectious Diseases, Tokyo (N.K.) - both in Japan; the Department of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi (H.A.T.N., L.H.H., D.-A.D.), and the Department of Bacteriology, Pasteur Institute, Nha Trang (L.T.L., H.T.D.) - both in Vietnam; the Department of Infectious Disease Epidemiology (B.J.Q., K.Z., K.M., S.F.) and the Centre for Mathematical Modelling of Infectious Diseases (B.J.Q., K.Z., S.F.), London School of Hygiene and Tropical Medicine, and the Institute for Infection and Immunity, St. George's University (J.H.) - both in London; the Department of Infection, Immunity, and Global Health, Murdoch Children's Research Institute (M.L.N., B.D.O., E.M.D., C.S., K.M.), and the Department of Paediatrics, University of Melbourne (C.S., K.M.), Melbourne, VIC, and the Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC (C.S.) - all in Australia; and the Center for Global Health, Charité-Universitätmedizin Berlin, Berlin (S.F.).
减少的肺炎球菌合疫苗 (PCV10) 计划,包括一剂主要剂量和一剂强剂量,在预防婴幼儿的疫苗类型肺炎球菌携带方面,与更密集的计划一样有效. 这一发现支持用于持续控制肺炎球菌病的成本有效策略.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 儿科 儿科 儿科
背景情况:
- 肺炎球菌联合疫苗 (PCV) 已经减少了疾病和殖民.
- 探索减少PCV计划可以降低成本,同时保持疾病控制.
研究的目的:
- 评估一剂初级加上一剂 (1p+1) 补充剂的10价值PCV (PCV10) 方案是否与控制肺炎球菌携带的其他方案无劣.
- 评估减少PCV疫苗接种计划的成本效益.
主要方法:
- 越南的一项集群随机试验比较了PCV10时间表:3p+0,2p+1,1p+1和0p+1.
- 从2016年到2020年,每年都会对婴儿和幼儿进行托运调查.
- 通过比较1p+1组与2p+1和3p+0组的疫苗血型携带率来评估非劣质性.
主要成果:
- 在预防婴幼儿的疫苗血清型携带方面,1p+1计划与2p+1和3p+0计划无差.
- 0p+1计划也显示出非劣势性,尽管对6A血清型的交叉保护较少.
- 没有观察到与PCV10相关的严重不良反应.
结论:
- 简化PCV10计划 (1p+1) 有效地保持了对疫苗血清型肺炎球菌携带的保护.
- 减少疫苗接种时间表为持续控制肺炎球菌提供了一种可行且可能节省成本的方法.
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