血神经纤维光的时间动态在患有临床前多发性硬化症的献血者中
Josefine Britze1, Margit Hørup Larsen1, Anders Gorm Pedersen1
1From the The Danish Multiple Sclerosis Centre (J.B., H.B.S., M.M., J.L.F.B., F.S.), Department of Neurology, Copenhagen University Hospital, Rigshospitalet; Department of Clinical Immunology (J.B., M.H.L., S.R.O., S.M.), Copenhagen University Hospital Rigshospitalet; Department of Clinical Medicine (J.B., M.M., O.B.P., S.R.O., J.L.F.B., F.S., S.M.), Faculty of Health and Medical Sciences, University of Copenhagen; Department of Health Technology (A.G.P.), Section for Bioinformatics, Technical University of Denmark; The Danish Cancer Institute (S.R.), Statistics and Data Analysis; The Danish Multiple Sclerosis Registry (M.M.); Department of Clinical Immunology (O.B.P.), Zealand University Hospital; Department of Clinical Immunology (B.A.J.), Aalborg University Teaching Hospital; Department of Clinical Immunology (C.E.), Aarhus University Teaching Hospital and Statens Serum Institut (H.U.), Copenhagen, Denmark.
多发性硬化症 (MS) 中的轴突损伤可能在症状出现前多达9年发生,由神经丝光链水平升高表明. 这种早期的损伤表明无症状的疾病活动和早期干预的潜在窗口.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统疾病,涉及脱髓化,炎症和神经退行.
- 神经纤维光链 (NfL) 是轴突损伤的标志物,可在周围血液中测量.
- 之前的研究表明,在多发性硬化症患者出现症状之前,NfL升高,但纵向数据有限.
研究的目的:
- 在多发性硬化症的症状前阶段调查个体内神经纤维光链水平的动态.
- 确定后来发展成MS的个体中NfL升高的频率和时间.
主要方法:
- 利用了来自丹麦献血者研究 (DBDS) 的储存血样本,这些样本来自被诊断患有多发性硬化症的献血者.
- 包括在第一个脱髓化症状出现前9年收集的样本.
- 用贝叶斯方法测量了血NfL水平,并将其与MS病例和健康对照进行了比较.
主要成果:
- 17%的前症状MS捐赠者在临床发病前9年间断地增加了NfL水平.
- 即使在初级进展性多发性硬化症病例中也观察到高NfL.
- 两组之间没有发现自我报告的幸福感有显著差异.
结论:
- 定期的轴突损伤发生在MS的前症状阶段,表明无症状的疾病活动.
- 这种通过NfL检测到的早期轴突损伤,可能在临床诊断前几年开始.
- 前症状阶段代表了MS干预的潜在治疗窗口.
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