组织糖组作为免疫激活和耐受性的调节者,由C型莱克和Siglecs介导
Eleonora Nardini1, Ernesto Rodriguez1, Yvette van Kooyk1
1Amsterdam UMC location Vrije Universiteit Amsterdam, Molecular Cell Biology and Immunology, De Boelelaan, Amsterdam 1117, The Netherlands; Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands; Amsterdam institute for Infection and Immunity, Cancer Immunology, Amsterdam, The Netherlands.
Seminars in immunology
|November 27, 2024
概括
糖体,或细胞糖层,塑造免疫细胞在专门的组织内的行为. 了解这些甘氨酸相互作用为基于免疫的诊断和治疗癌症和自身免疫等疾病提供了新的途径.
科学领域:
- 免疫学 免疫学 免疫学
- 葡萄糖生物学 葡萄糖生物学
- 细胞微环境 细胞微环境
背景情况:
- 免疫系统的功能依赖于由细胞-细胞和细胞-矩阵相互作用形成的专门的微环境 ().
- 葡萄糖体,包括所有细胞产生的葡萄糖和葡萄糖结合物,是这些利基的关键但未被充分研究的组成部分.
- 细胞表面的甘氨酸会影响免疫细胞的活动,贩运和通过与甘氨酸结合受体的相互作用传递信号.
研究的目的:
- 审查组织糖化对宿主免疫细胞的影响.
- 探索针对新型诊断和免疫疗法的糖体向的潜力.
- 要突出 glycan 介导的免疫调节如何可以恢复疾病中的免疫平衡.
主要方法:
- 关于研究葡萄糖在免疫细胞功能中的作用的文献综述.
- 分析不同组织 (如大脑,肠道) 的改变糖化如何影响免疫反应.
- 检查针对甘氨酸与免疫细胞相互作用的治疗策略.
主要成果:
- 组织特定的糖化模式显著影响免疫细胞的行为和恒常性.
- 糖体的变化与免疫耐受性 (例如胎盘) 和炎症 (例如肠道) 有关.
- 干扰糖基化通路为治疗干预提供了机会.
结论:
- 葡萄糖体是免疫细胞相互作用的关键调节者.
- 向糖基化为开发自身免疫性疾病和癌症的诊断和治疗方法提供了有希望的策略.
- 通过糖调节恢复免疫平衡是潜在的治疗目标.
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