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成年患有线粒体肌肉病变的成年患者的素饮食

Heidi E E Zweers¹, Sophie H Kroesen², Gijsje Beerlink¹

¹Department of Gastroenterology and HepatologyDietetics, Radboudumc, Nijmegen, the Netherlands; Radboud Centre for Mitochondrial Medicine (RCMM), Nijmegen, the Netherlands.

Molecular genetics and metabolism

|November 27, 2024

概括

修改后的阿特金斯饮食 (MAD) 在线粒体肌肉病 (MM) 患者中显示出可变的可行性和安全性. 它可能不适合那些有线粒体DNA缺失的人,需要密切监测不良事件.

科学领域:

神经学神经学
代谢障碍代谢障碍代谢障碍
营养科学营养科学

背景情况:

线粒体肌肉病 (Mitochondrial myopathy,MM) 是一种衰弱的神经肌肉疾病.
目前MM的治疗选择有限.
修改的阿特金斯饮食 (MAD) 是一种可以提供治疗益处的性饮食.

研究的目的:

在被诊断为线粒体肌肉病变 (MM) 的患者中研究修改的阿特金斯饮食 (MAD) 的可行性,安全性和有效性.
在这个患者群体中评估碳水化合物限制饮食的耐受性和潜在益处.

主要方法:

在基因确诊的线粒体疾病患者中实施了为期十二周的修改阿特金斯饮食 (MAD) 干预措施.
通过饮食坚持和水平来评估可行性.
通过不良事件跟踪监测安全性,并使用运动性能和肌肉强度测试评估有效性.

主要成果:

20名患者中有8人完成了为期12周的MAD干预.
一些不良事件,包括骨髓溶解和疲劳,导致一些患者停止治疗.
个人在心肺健康,肌肉性能,葡萄糖耐受性和其他症状方面有所改善,尽管结果有显著差异.

结论:

在MM患者中MAD的可行性,安全性和有效性是高度可变的.
由于不良事件导致的线粒体DNA缺失,MAD可能不适合MM患者.
密切监测不良事件至关重要,需要进一步研究预测因素和不那么严格的饮食.

关键词:

不良事件是不良事件.基因饮食是基因的饮食.最大增量测试最大增量测试线粒体DNA的删除线粒体肌肉病变是一种线粒体肌肉病变.修改过的阿特金斯饮食

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