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双金属纳米酶可以有效地去除肉中的Enterococcus faecalis生物膜,并治疗周围感染

Yanya Qiao¹, Yanfeng Shi², Mengyu Jiao¹

¹Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China; School of Stomatology, Qingdao University, Qingdao 266023, China.

Journal of colloid and interface science

|November 27, 2024

概括

新的双金属铁纳米酶 (ZFNs) 有效地消除Enterococcus faecalis (E. faecalis) 生物膜,这是持续根管感染的常见原因. 这些ZFN显示出作为一种安全有效的替代现有治疗方法的承诺.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
微生物学微生物学

背景情况:

由于耐药的Enterococcus faecalis (E. faecalis) 生物膜,脉和周围感染具有挑战性.
目前的治疗方法在消除这些持久生物膜方面存在局限性.

研究的目的:

合成和评估双金属铁纳米酶 (ZFNs) 对它们对E. faecalis生物膜的有效性.
研究ZFN在激活过氧化 (H2O2) 中的机制,以产生用于生物膜消除的基激素.

主要方法:

合成具有增强过氧化酶类 (POD类) 活性的Zn-Fe纳米酶 (ZFNs).
试验ZFN与H2O2相结合的E. faecalis生物膜在体外和根运河感染模型中.
评估生物膜无活化百分比,生物膜形成的破坏和生物安全性.

主要成果:

ZFNs表现出增强的POD类活动,优化了Fe站点的电子结构.
低度的ZFNs (20 μg mL-1) 与H2O2 (200 μM) 实现了95%的E. faecalis无活化,并破坏了生物膜的形成.
在一个具有令人满意的生物安全性的根运河模型中,ZFNs显示了与3%的甲 (NaOCl) 相似的生物膜清除效应.

结论:

Zn-Fe纳米酶 (ZFNs) 提供了一种有效的策略来对抗E. faecalis生物膜.
作为一种新的根管灌解决方案,ZFNs显示出显著的潜力,用于治疗脉和周围脉感染.
这种方法为解决内牙治疗方面的挑战提供了一个有希望的新途径.

关键词:

菌 (Enterococcus faecalis) 是一种菌.纳米酶纳米酶是一种纳米酶.类似过氧酶的活性.皮质和周围皮质感染.根运河治疗根运河治疗

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