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一一睹从大流行SARS-CoV-2感染的生存

Santosh K Rath¹, Ashutosh K Dash², Nandan Sarkar³

¹School of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, 248009, India.

Bioorganic chemistry

|November 27, 2024

概括

本综述检查了潜在的抗体和药物来对抗COVID-19,这是由SARS-CoV-2引起的全球流行病. 它讨论了针对病毒入侵的治疗方法以及正在开发的各种治疗剂,以对抗疾病及其并发症.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

由SARS-CoV-2引起的COVID-19为全球健康带来了重大挑战,并带来了各种次要并发症.
风险评估失败和病毒对多个器官系统的影响加剧了流行病的严重程度.
目前的治疗方法和疫苗有希望,但缺乏对SARS-CoV-2的完全有效性.

研究的目的:

审查针对SARS-CoV-2的潜在治疗策略.
为 COVID-19 治疗突出有前途的单克隆抗体和候选药物.
讨论这些药物的合成方案和临床开发.

主要方法:

科学出版物和临床试验数据的文献综述.
针对SARS-CoV-2尖端蛋白和ACE2相互作用的抗体的识别和分析.
汇编有关不同抗病毒药物在不同发展阶段的信息.

主要成果:

一些单克隆抗体,包括托西利祖马布和干扰素变体,显示出抑制病毒进入的潜力.
一系列药物,如Favipiravir,Remdesivir和Baricitinib,正在研究它们对抗COVID-19的有效性.
详细介绍了这些药物的合成方案和正在进行的临床项目.

结论:

单克隆抗体通过阻断病毒与宿主细胞的附着提供了一个潜在的策略.
多种候选药物正在开发中,代表了管理COVID-19的多种治疗方法.
进一步的研究和临床试验对于确定这些治疗方法的安全性和有效性至关重要.

关键词:

ACE2,用于抗击COVID-19的药物抗体是一种抗体.在 COVID-19 疫情中,新型冠状病毒新型冠状病毒.肺炎是一种肺炎.

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