通过增材制造的三重周期性最小表面结构来实现下重建板的功能改进
Zaki Alomar1, Morteza Aramesh2, Andreas Thor3
1Free University of Bozen-Bolzano, Bolzano, Italy; Department of Materials Science and Engineering, Division of Biomedical Engineering, Uppsala University, Sweden.
Journal of the mechanical behavior of biomedical materials
|November 27, 2024
概括
下重建板的新增剂制造设计促进骨生长,以提高接受放射治疗的患者的生存率,提高植入物的功能和寿命.
科学领域:
- 生物材料工程 生物材料工程
- 口腔和牙面部外科手术
- 医疗器械设计 医疗器械设计
背景情况:
- 通过增材制造的患者特异性植入物为口腔和大面部重建提供了更好的适合性.
- 辐射疗法可以损害被辐射的组织中的血管性,导致诸如板块松动和下重建中的暴露等并发症.
- 在放射治疗前加速骨生长可能会提高下重建板的存活率.
研究的目的:
- 提出和评估一种使用三次周期最小表面 (TPMS) 结构的新下重建板设计.
- 为了促进骨质整合,并在辐射患者的愈合过程中提供机械支持.
- 在具有挑战性的临床场景中改善植入物的功能和存活率.
主要方法:
- 使用激光粉床融合制造六个不同的TPMS结构.
- 通过三点曲试验进行机械评估,以评估承载能力.
- 在体外细胞活力测试以确定生物相容性和细胞增殖.
主要成果:
- 所有制造的TPMS结构都表现出能够承受记录的咬伤力的机械完整性.
- 状腺结构表现出较低的曲模块,这表明下重建的机械性能有利.
- 在体外试验证实了在所有评估的TPMS结构中高细胞增殖和优异的细胞粘附.
结论:
- 基于TPMS的下重建板设计显示了改善骨整合和机械支的巨大潜力.
- 这种设计方法可能会提高植入物功能和更高的存活率,特别是在接受放射治疗的患者中.
- 对这种设计概念的进一步研究可以为复杂的口腔和口面部重建提供更强大的解决方案.
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