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载有硫素的纳米框架:通过诱导铁灭症来治疗膀癌症的新前沿

Xieyu Yan¹, Quanjin Li¹, Shuai Xiao¹

¹Department of Urology, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, No.61, west Jiefang Road, Changsha 410011, China.

Colloids and surfaces. B, Biointerfaces

|November 27, 2024

概括

这项研究引入了Pt/Co-BNN@SAS纳米颗粒,通过耗尽谷氨 (GSH) 来诱导癌细胞中的铁亡. 这种新的方法针对瘤的抗氧化活性,为癌症治疗提供了一种新的策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

瘤细胞具有高的抗氧化活性,限制铁灭菌的有效性并促进耐药性.
诱导铁死是一种有前途的癌症治疗策略.
向谷氨 (GSH) 是克服瘤抗氧化防御的关键.

研究的目的:

开发一种新的纳米药物输送系统,用于诱导癌细胞中的铁亡.
通过使用sulfasalazine (SAS) 装载的纳米颗粒来研究通过GSH枯竭诱导铁灭的机制.
评估开发的纳米颗粒在治疗膀癌症中的有效性.

主要方法:

硫沙 (SAS) 装载的纳米框架自蚀刻的Pt-Co纳米 dendrites (Pt/Co-BNN@SAS) 的合成.
评估Pt/Co-BNN的过氧酶 (POD) 活性及其在活性氧物种 (ROS) 生成和GSH耗尽中的作用.
评估SAS对系统xc-的抑制及其对GSH耗尽的贡献.
在膀癌细胞中分析脂质过氧化物 (LPO) 积累,谷氨过氧化酶4 (GPX4) 抑制和铁死诱导.

主要成果:

Pt/Co-BNN@SAS纳米颗粒有效地减少了瘤细胞中的GSH.
这些纳米粒子催化了ROS的产生,并抑制了GPX4的活性.
SAS释放抑制了囊的吸收,进一步加快了GSH的耗尽.
在膀癌细胞中观察到显著的LPO积累和ferroptosis诱导.
实现了膀癌细胞迁移的抑制.

结论:

Pt/Co-BNN@SAS纳米颗粒通过通过GSH枯竭诱导铁亡,为癌症治疗提供了一种新的策略.
纳米药物输送系统有效地克服了瘤的抗氧化防御.
这种方法对治疗膀癌很有希望,需要进一步研究纳米药物生物相互作用.

关键词:

铁化是铁化的一种.这是GSHGSH.一个纳米框架.在POD POD中,可以使用POD.苏尔法萨拉酸盐是一种硫酸盐.

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