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Updated: Jun 6, 2025

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers
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酸酶PP1通过促进RNA聚合酶II暂停释放来维持全球转录

Zhenning Wang1, Aixia Song1, Bolin Tao1

  • 1Cancer Institute & Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Molecular cell
|November 27, 2024
PubMed
概括

酸酶1核向子单元 (PNUTS) -PP1复合体通过促进RNA聚合酶II暂停释放来意外地维持基因激活. 破坏这个复合体严重损害了转录,揭示了PP1在全球基因表达中的新角色.

关键词:
7SK snRNP 7SK snRNP 7SK snRNP 7SK snRNP 7SK snRNP 7SK snRNP 7SK snRNP 7SK snRNP 7SK在INTACTAC中使用.普斯 (PNUTS) 是一个全年普斯.PNUTS-PP1 是一个国家.PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1 PP1在PP2A中,PP2A是PP2A.的RNA聚合酶II.暂停暂停暂停的时间酸酶是一种酸酶.转录 转录 是一种转录.

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