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  • 1Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai, China; Shanghai Key Laboratory of Fundus Disease, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.

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病态近视 (PM) 与高近视 (HM) 相比,涉及明显的代谢差异. 识别这些代谢变化,如4-基-l-胺酸水平,为PM提供了洞察力.

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科学领域:

  • 眼科医生 眼科 眼科
  • 代谢学 代谢学 代谢学
  • 生物化学 生化学

背景情况:

  • 病态近视 (PM) 与导致失明的眼部疾病有关.
  • PM和高近视 (HM) 是不同的疾病,但它们之间的区别仍然不清楚.
  • 了解PM病原体对于预防视力丧失至关重要.

研究的目的:

  • 为了全面识别病态近视 (PM) 的代谢变化.
  • 为了区分PM,高近视 (HM) 和低近视 (LM) 之间的代谢概况.
  • 探索特定代谢物和途径在PM发展中的作用.

主要方法:

  • 使用了超高性能液体色谱/并联质谱 (UPLC-MS/MS).
  • 对三个组的代谢物概况进行比较分析:PM,HM和LM.
  • 采用了Venn图和接收器运行特征 (ROC) 曲线分析.

主要成果:

  • 134,125和81个差异性代谢物在比较中被确定.
  • 在PM与HM和PM与LM之间重叠的32种差异性代谢物.
  • 确定的主要危险因素包括高的4-基-l-胺酸和低的半化物;氨酸,酸盐和谷氨酸代谢发生了显著的变化.

结论:

  • 在PM和HM患者之间存在显著的代谢差异.
  • 代谢变化,特别是氨基酸代谢,与PM相关.
  • 这些发现为潜在的病理近视的分子机制提供了新的见解.