相关实验视频
Updated: Jun 6, 2025

10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
9.8K
高度B细胞淋巴瘤:双击和非双击
Lianqun Qiu1, L Jeffrey Medeiros1, Shaoying Li1
1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Human pathology
|November 27, 2024
概括
高度B细胞淋巴瘤 (HGBL) 的分类已经发展,最近的更新区分了DLBCL/HGBL等亚型,具有特定的基因重组. 了解这些HGBL分类对于有效的治疗策略至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 高度B细胞淋巴瘤 (HGBL) 约占非霍奇金淋巴瘤的2%.
- 患有HGBL的患者通常在标准治疗后表现出耐药或复发性疾病.
- 近几十年来,HGBL的分类经历了重大修订.
研究的目的:
- 为提供高级B细胞淋巴瘤 (HGBL) 的最新审查.
- 专注于临床病理学特征,诊断,分子遗传学和HGBL亚组的病变发生.
- 讨论诊断方法,差异诊断和挑战,特别是B型淋巴细胞白血病/淋巴瘤.
主要方法:
- 目前文献和分类系统的审查 (WHO-HAEM5,ICC).
- 对HGBL亚型的临床病理学,分子遗传和病原遗传特征的分析.
- 讨论诊断策略和差异诊断方面的考虑.
主要成果:
- 世界卫生组织分类的第五版 (WHO-HAEM5) 定义了两个主要的HGBL类型:DLBCL/HGBL与MYC和BCL2重排,和HGBL,没有另有说明 (HGBL-NOS).
- 根据形态,WHO-HAEM5将某些DLBCL/HGBL与MYC和BCL6重新排列重新分类为DLBCL或HGBL-NOS.
- 国际共识分类 (ICC) 承认WHO-HAEM5类别,并添加HGBL与并发的MYC和BCL6重新排列作为临时实体.
结论:
- 最近的分类改进了对HGBL的理解,影响了诊断和治疗.
- 基于形态学和分子遗传学的准确分类对于管理HGBL至关重要.
- 从B型淋巴细胞白血病/淋巴瘤区分HGBL仍然是一个关键的诊断挑战.
相关概念视频
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
Fixing Double-strand Breaks
12.3K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
12.3K
T Cell Activation and Clonal Selection
669
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
669

