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Updated: Jun 6, 2025

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

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Published on: September 8, 2017

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通过PAF1介导的转录重编程在晚期前列腺癌中赋予了多塞塔克塞尔耐药性

Sakthivel Muniyan1, Raghupathy Vengoji1, Rama Krishna Nimmakayala1

  • 1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Cancer letters
|November 27, 2024
PubMed
概括

前列腺癌 (PCa) 通常会对多塞素化疗产生耐药性. 这项研究表明,PAF1蛋白 (Paf1/RNA聚合酶II复合体成分) 通过调节癌症干细胞特征来驱动这种抵抗.

关键词:
在CRPC中使用CRPC.癌症类似干细胞的细胞.多细胞有机体生长的多细胞有机体生长.一个PAF1的PAF1.治疗耐药性 治疗耐药性

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