对于严重和 fulminant Clostridioides difficile 感染的辅助时代环素的结果
Christen J Arena1, Rachel M Kenney2, Mayur Ramesh3
1Henry Ford Hospital, Department of Pharmacy, Detroit, USA; Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Department of Pharmacy Practice, Detroit, USA.
概括
埃拉维环素 (ERV) 可能有助于治疗严重或突发性Clostridioides difficile感染 (CDI). 接受ERV治疗的患者往往免疫功能低下,病情危急,结果包括胆管切除或30天死亡率.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 困难菌感染 (CDI) 构成重大威胁,特别是在严重或突发病例中.
- 标准治疗对重症患者可能有局限性.
- 埃拉瓦环素 (ERV) 是一种具有广泛活性的抗生素.
研究的目的:
- 评估使用埃拉瓦环素 (ERV) 作为严重或突发性Clostridioides difficile感染 (CDI) 的辅助疗法.
- 描述患者的特征和结果,包括胆管切除率和死亡率.
主要方法:
- 一项横截面研究包括75名住院的成年患者,患有重症或 fulminant CDI,接受了ERV加标准治疗抗生素治疗.
- 患者接受ERV≥24小时;排除包括之前的胆管切除术或ERV的非CDI指示.
- 主要结局:由于C. difficile造成的集体切除术. 二次结果:30天所有原因的死亡率.
主要成果:
- 在75名患者中,33%患有重症,67%患有 fulminant CDI;31%患有耐火性疾病.
- 患者通常免疫功能低下 (40%) 并需要重症监护 (61%).
- 11% (14.7%) 的患者需要进行大肠切除术,37%的患者在30天内死亡.
结论:
- 埃拉瓦环素 (ERV) 显示出作为严重或 fulminant CDI 的辅助治疗的潜力.
- 接受ERV治疗的患者经常免疫功能低下,病情危急.
- 需要进一步的比较研究来证实辅助ERV在CDI管理中的影响.
相关概念视频
01:17Drugs for Treatment of Diarrhea-Predominant IBS
147
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
147
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
96
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
96
01:18Endocarditis III: Medical Management
2
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
2
01:28Pleural Effusion II: Symptoms and Management
154
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
154
01:26Endoscopic Procedures V: ERCP
86
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Patient...
86
01:27Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K