通过基于胆的离子液体增强通过皮肤传递胰岛素
1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
International journal of pharmaceutics
|November 27, 2024
概括
使用基于胆的离子液体 (ILs) 的两步方法与单步方法相比,显著增强了通过皮肤递送胰岛素. 这一策略改善了糖尿病老鼠的血糖控制,显示了非侵入性药物输送的前景.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 离子液体 (ILs) 作为化学透增强剂 (CPE) 进行了探索,用于通过皮肤递送药物.
- 在单步策略中,高粘度和药物-IL亲和力可以阻碍宏分子药物扩散和释放.
- 为胰岛素等生物药物开发有效的透皮输送系统仍然是一个挑战.
研究的目的:
- 为了研究使用基于胆的ILs来增强通过皮肤输送胰岛素的两步策略.
- 为了比较两步策略与一步方法的有效性.
- 评估ILs对胰岛素稳定性,释放动力学和皮肤透性的影响.
主要方法:
- 一个两步的透皮输送策略,涉及用胆基ILs进行预处理,然后应用胰岛素溶液.
- 在糖尿病老鼠模型中进行体外和体外研究,以评估血糖降低.
- 分子动力学模拟和超皮肤水损失测量以分析皮肤透和屏障功能.
- ILs的物理特征和胰岛素稳定性和释放的评估.
主要成果:
- 与单步方法相比,两步策略显著提高了胰岛素透率和通过皮肤递送.
- 胆酸盐 ([Ch][Ci]) 和胆酸盐 ([Ch][Ge]) 在两步方法中表现出优异的性能.
- 用[Ch][Ge]进行的两步治疗有效地在8小时内降低了糖尿病大鼠的血糖水平.
- 发现ILs可以透角层,打开紧密的结口,促进胰岛素的运输.
结论:
- 使用基于胆的ILs的两步策略是增强通过皮肤输送胰岛素的有希望的方法.
- [Ch][Ci]和[Ch][Ge]显示出显著的潜力,其中[Ch][Ge]提供快速的葡萄糖控制.
- ILs通过修改皮肤屏障特性来改善皮肤间的传递,克服了单步方法的局限性.
- 根据初步的安全性和疗效数据,对基于IL的透皮系统的进一步研究是有必要的.
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