选择性皮肤冠状动脉干预后内源型冠状动脉微血管功能障碍的预后值
Kai Nogami1, Yoshihisa Kanaji1, Eisuke Usui1
1Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital.
概括
皮肤通冠状动脉干预 (PCI) 后的内源型冠状动脉微血管功能障碍 (E-CMD) 与慢性冠状动脉综合征 (CCS) 患者的预后状况较差有关. 识别PCI后的E-CMD可以帮助指导治疗策略,以改善患者的治疗结果.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 医学诊断 医学诊断 医学诊断
背景情况:
- 冠状动脉微血管功能障碍 (CMD) 表示全球冠状动脉流量储备 (G-CFR) 受到损害,与预后不佳有关.
- 内源型心血管疾病 (E-CMD) 呈现出正常或轻微减少的高血压冠状动脉流和升高的静止流,使其与传统心血管疾病区别开来.
- 评估皮肤穿刺术后冠状动脉干预 (PCI) CMD的预后影响,特别关注E-CMD,对于了解患者的治疗结果至关重要.
研究的目的:
- 评估慢性冠状动脉综合征 (CCS) 患者PCI后CMD,特别是E-CMD的预后价值.
- 确定E-CMD是否独立预测PCI后的CCS患者的主要不良心脏和脑血管事件 (MACCE).
主要方法:
- 一项回顾性研究包括320名接受PCI的CCS患者.
- 心脏磁共振成像 (CMR) 用于评估G-CFR和静止心肌流量.
- 患者根据PCI后的CMD状态 (G-CFR <2.0) 和E-CMD分类进行分类,MACCE追踪时间中位数为2.5年.
主要成果:
- 在43.4%的患者中,PCI后的CMD存在,在63.3%的CMD患者中发现了E-CMD.
- 在8.1%的患者中,MACCE发生,CMD患者的发病率较高 (11.5%),而没有CMD患者的发病率较高 (5.5%).
- E-CMD与显著更高的MACCE率 (14.8%) 和独立预测的MACCE (HR 3.24;P=0.004) 相关.
结论:
- 在PCI后的CMD,特别是E-CMD,与CCS患者的不良结果有显著的关联.
- 鉴定PCI后的CMD,包括E-CMD,可以为CCS患者的治疗策略提供信息.
- 进一步研究管理PCI后的E-CMD可能会改善患者的长期预后.
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