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在2型糖尿病诊断前几十年,心血管疾病的发生率增加了2倍:一项全国性的注册研究
Christine Gyldenkerne1, Johnny Kahlert2, Pernille G Thrane3
1Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Journal of the American College of Cardiology
|November 27, 2024
概括
在诊断前长达30年的2型糖尿病患者中,心血管疾病 (CVD) 的风险显著增加. 对于那些有T2DM风险的人来说,早期预防策略至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 患有2型糖尿病 (T2DM) 的人面临心血管疾病 (CVD) 的风险更高.
- 心血管疾病发生率升高与T2DM诊断之间的时间关系尚不清楚.
研究的目的:
- 调查心血管疾病在T2DM诊断前30年和T2DM诊断后5年的发生情况.
- 将T2DM患者的心血管疾病发病率与匹配的对照组进行比较.
主要方法:
- 采用了综合病例控制和队列研究设计.
- 数据包括丹麦 (2010-2015年) 的T2DM诊断,并与一般人口的比较进行了匹配.
- 心血管疾病被定义为心肌梗塞或缺血性中风;使用了后勤和Cox回归模型.
主要成果:
- 这项研究分析了127,092名T2DM患者和381,023个比较.
- 在诊断前30年,T2DM组中心血管疾病的患病率更高,几率比率 (ORs) 越来越接近诊断.
- 在诊断后,T2DM组的5年心血管疾病发病率仍然显著增加 (危险比率[HR]:2.20).
结论:
- T2DM与心血管疾病事件的风险增加了一倍,最早在诊断前30年开始.
- 这些发现强调了对易患T2DM的个体采取早期和全面的预防措施的必要性.
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