带有支气管肺功能障碍的早产新生儿的肺高血压:一个元分析
Dwayne Mascarenhas1,2, Marwa Al-Balushi1,2, Aida Al-Sabahi1,2
1The Hospital for Sick Children, Toronto, Ontario, Canada.
Archives of disease in childhood. Fetal and neonatal edition
|November 27, 2024
概括
在患有支气管肺功能失调 (BPD) 的早产婴儿中,肺高血压 (PH) 是常见的,并且随着BPD的严重程度而增加. BPD-PH与较高的死亡率和不良的神经发育结果有关.
科学领域:
- 新生儿医学 新生儿医学
- 儿童心脏病学 儿童心脏病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 关于肺高血压 (PH) 发生率和风险因素在早产婴儿患有支气管肺张力症 (BPD) 的知识缺口存在.
- 在这个脆弱人群中,BPD-PH对短期和长期结果的影响需要进一步阐明.
研究的目的:
- 系统地审查和元分析早产婴儿BPD-PH的发病率.
- 确定与BPD-PH.发展相关的重大风险因素.
- 评估诊断为BPD-PH的早产婴儿的短期和长期结果.
主要方法:
- 我们对PubMed,Embase,Cochrane CENTRAL和CINAHL进行了全面的搜索.
- 研究包括早产婴儿 (<37周妊娠年龄或<2500克出生体重) 患有BPD-PH与没有PH的BPD相比.
- 从开始到2023年4月5日的数据被提取,重点关注发病率,风险因素和结果.
主要成果:
- 分析了44项涉及7677名早产婴儿的观察性研究.
- 在轻度,中度和严重的BPD中,PH发生率分别为5%,18%和41%.
- 显著的危险因素包括对于妊娠年龄来说小,死性肠球炎,早期PH诊断和严重的BPD. BPD-PH与死亡率增加,通风/住院时间长,神经发育障碍风险更高有关.
结论:
- 在早产婴儿中,肺高血压的发生率随着BPD的严重程度而增加.
- BPD-PH是增加死亡率和短期和神经发育不良结果的重要危险因素.
- 这些发现凸显了早期识别和管理BPD早产婴儿PH的关键需求.
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