直接口服抗凝剂测定利用和相关出血事件:一个多中心队列研究
Brandon Stretton1,2,3, Joshua Kovoor1,2,3, Stephen Bacchi1,3,4
1Adelaide Medical School, Faculty of Health and Medical Science, University of Adelaide, Adelaide, Australia.
Hospital practice (1995)
|November 28, 2024
概括
在患有出血事件的患者中,直接口服抗凝剂 (DOAC) 的水平差异很大. 较高的DOAC血度与出血严重程度无关,但与增加的抗凝剂逆向注射有关.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 血液学 血液学 血液学
背景情况:
- 关于直接口服抗凝剂 (DOAC) 测定血度及其与出血事件或输血需求的关联的证据有限.
- 了解这些关联对于治疗出血的抗凝血药患者至关重要.
研究的目的:
- 在紧急出血患者中描述DOAC分析的使用和血水平.
- 调查DOAC血水平与出血严重程度之间的关联.
主要方法:
- 一个多中心的回顾性队列研究,包括86名患有紧急出血和DOAC检测的患者.
- 分析包括线性和二进制物流回归来评估结果.
主要成果:
- 中位数DOAC测定血水平为122.9 ng/ml,测定后平均4.8小时进行测定.
- DOAC 血水平与出血类型或严重程度没有显著关联.
- 每增加10个单位/毫升的DOAC测定血水平与反凝剂逆向注射的几率增加4%相关.
结论:
- 在出血患者中,DOACs的血水平呈现出广泛的范围.
- 较高的DOAC血水平并不预示出更糟糕的出血结果或增加的输血需求.
- 较高的DOAC血水平与给予逆转药物的可能性更高有关.
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