运动训练以性别依赖的方式对抗预糖尿病人的能量限制引起的线粒体能力受损
Magni Mohr1,2, Jerónimo Aragón Vela3, May-Britt Skoradal1
1Centre of Health Sciences, Faculty of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands.
Scandinavian journal of medicine & science in sports
|November 28, 2024
概括
运动训练可以防止因卡路里限制导致的线粒体功能障碍,在患有糖尿病前期和代谢综合征的老年人中. 这种干预可以保护骨肌肉功能,特别是在女性身上.
科学领域:
- 运动生理学 运动生理学
- 代谢健康 代谢健康
- 衰老研究研究 衰老研究
背景情况:
- 糖尿病前期和代谢综合征与骨肌肉线粒体功能受损有关.
- 能量限制虽然有利于减肥,但可以加剧线粒体功能障碍.
- 了解在老年人群中保持线粒体容量的干预措施至关重要.
研究的目的:
- 调查运动训练是否可以抵消能量限制引起的骨肌肉线粒体容量的损害.
- 在这种背景下,探索性别对运动训练有效性的影响.
- 评估关键线粒体酶和肌肉糖原的变化.
主要方法:
- 一项为期16周的随机对照试验,涉及50名久坐不动的成年人 (55-70岁),患有糖尿病前期和代谢综合征.
- 参与者被分配到运动训练加饮食建议 (EX-DI) 或仅饮食建议 (DI) 中.
- 在干预前和后测量了线粒体酶 (CS,HAD,SOD2) 和肌肉糖原的最大活性和蛋白质丰度.
主要成果:
- 仅仅饮食建议 (DI) 显著损害了酸盐合成酶 (CS) 和3-基亚基-CoA脱酶 (HAD) 的最大活性和SOD2/CS蛋白质表达.
- 运动训练与饮食建议 (EX-DI) 结合,可以预防这些障碍.
- 男人,但不是女性,在两组中都显示出最大CS活动的下降.
结论:
- 16周的运动训练有效地抵消了骨肌肉线粒体功能的能量限制引起的损伤,在患有糖尿病前期和代谢综合征的老年人中.
- 运动是维护线粒体健康的重要组成部分,在减肥干预期间,在这个人口群体中.
- 观察到性别特异性反应差异,男性对线粒体衰退的敏感性更大.
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