Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

The <i>Staphylococcus aureus</i> carotenoid staphyloxanthin modifies the structure of phosphoglycerol lipid bilayers.

bioRxiv : the preprint server for biology·2026

Same author

Introducing non-enzymatic crosslinks into atomistic simulations of collagen fibrils.

Bioinformatics (Oxford, England)·2026

Same author

SITH: A quantum-chemical framework for predicting bond destabilization in stretched molecules.

The Journal of chemical physics·2026

Same author

Localized carbon deposition enables trimming of photonic integrated circuits.

Nature communications·2026

Same author

Extrinsic polarity cues control lamination versus cluster-based organization in vertebrate retinal development.

iScience·2026

Same author

KIMMDY: a biomolecular reaction emulator.

Nature communications·2026

Search research articles

相关实验视频

Updated: Jun 6, 2025

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

基于原折叠和展开的响应式3D打印微结构.

Philipp Mainik^1,2, Camilo Aponte-Santamaría³, Magdalena Fladung⁴

¹Institute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University, 69120, Heidelberg, Germany.

Small (Weinheim an der Bergstrasse, Germany)

|November 28, 2024

概括

研究人员开发了一种用于3D激光打印的基于原蛋白的新型墨水,为组织工程创造了响应敏捷的生物材料. 这一进步使复杂的微观结构能够精确制造,并有可能用于4D打印应用.

关键词:

4D打印是一种4D打印.细胞外矩阵是细胞外矩阵.自动组装的自动组装机对刺激有反应的材料.采用双光子激光打印方式打印.

更多相关视频

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

Published on: May 9, 2016

Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels

Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels

Published on: February 12, 2016

相关实验视频

Last Updated: Jun 6, 2025

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

Published on: May 9, 2016

Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels

Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels

Published on: February 12, 2016

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
生物医学工程生物医学工程

背景情况:

细胞外矩阵对于组织工程至关重要,因为原提供机械稳定性并调节细胞过程.
双光子3D激光打印允许生物材料的高分辨率结构化,但原体微印刷一直局限于简单的设计.
开发先进的生物材料是再生医学和生物医学应用的关键.

研究的目的:

介绍一种使用新型油墨系统3D微印刷原蛋白的可访问方法.
为了展示定义的3D微观结构与亚细胞分辨率的制造.
探索这些微结构作为 4D 打印响应生物材料的潜力.

主要方法:

一种可在室温下储存的 I 型原甲胺 (ColMA) 油墨系统的配方.
使用商用二光子3D激光打印机精确3D微印刷ColMA墨水.
优化打印参数和结果微观结构的表征,包括热反应分析和分子动力学模拟.

主要成果:

一种室温稳定的ColMA墨水已成功开发,用于精确的3D微印.
使用优化的打印参数制造了具有可控几何形状的定义3D微结构.
打印的原体微结构表现出可逆的热反应,表明原体成功折叠/展开,并得到模拟的支持.

结论:

这项研究引入了一种可访问的对原体3D微印刷的方法,使得复杂和响应敏捷的生物材料的创造成为可能.
开发的ColMA墨水和印刷方法促进了适合先进组织工程的微结构的制造.
这项工作为设计用于4D (微) 打印应用的新型响应性生物材料开辟了新的途径.