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响应pH的表面功能化螺丝在治疗植入物相关的S. aureus骨髓炎与生物膜形成的有效性

Hang Zhou¹, Youliang Ren¹, Kaixiong Zou²

¹Department of Orthopaedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, P. R. China.

Advanced healthcare materials

|November 28, 2024

概括

装有抗微生物的新型螺丝显示对黄金葡萄球菌骨髓炎的持续有效性. 这些响应pH的植入物消除细菌,促进骨的整合,为植入物相关的感染提供了一个有希望的解决方案.

科学领域:

生物材料科学生物材料科学
整形外科手术整形外科手术
传染性疾病传染性疾病

背景情况:

植入物相关的黄金葡萄球菌骨髓炎 (IASO) 导致高水平的骨科植入物失败.
细菌殖民发生在骨髓和骨质细胞沟-沟网络 (OLCN).

研究的目的:

开发用于IASO处理的螺丝 (Ti-NTs-P-A) 上的pH响应的抗微生物载纳米管.
为了评估Ti-NTs-P-A螺丝的抗菌疗效和骨质整合.

主要方法:

制造的Ti-NTs-P-A螺丝与pH响应的HC36释放.
殖民地形成单位测定以评估抗菌活性.
转录组测序以分析细菌反应.
在IASO模型中评估骨植入物接触率和感染控制率.

主要成果:

Ti-NTs-P-A螺丝证明了持续杀死超过65%的金黄色细菌.
观察到显著的pH响应HHC36释放和杀菌活性.
转录组分析显示,细菌核糖体形成和氨酸生物合成中断.
与标准螺丝相比,Ti-NTs-P-A螺丝显示了2.3倍高的骨植入物接触比率.
在IASO模型中实现了80%的感染控制率和增强的骨质整合.

结论:

Ti-NTs-P-A螺丝提供pH响应的抗菌特性,用于消除IASO中的细菌.
这些新型植入物促进骨质整合,为植入物相关的感染提供双重作用的解决方案.

关键词:

抗微生物类的抗微生物.生物膜是一种生物膜.与植入物相关的黄金杆菌骨髓炎骨质整合骨质整合具有pH响应性的

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