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Updated: Jun 6, 2025

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在皮层发育过程中,MYT1L缺乏会损害刺激神经元的轨迹

Allen Yen1,2, Simona Sarafinovska1,2, Xuhua Chen1,3

  • 1Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.

Nature communications
|November 28, 2024
PubMed
概括

MYT1L (Myt1类似) 的突变破坏神经元发育和基因表达,影响神经元成熟. 这项研究揭示了MYT1L.

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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