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Updated: Apr 28, 2026

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species
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FMR1在遗传上与DISC1相互作用,以调节谷氨基酶突触生成

Takato Honda1,2,3,4, Kazuki Kurita5, Yuko Arai5

  • 1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusettes Institute of Technology (MIT), Cambridge, MA, USA. takatoh@mit.edu.

Schizophrenia (Heidelberg, Germany)
|November 28, 2024
PubMed
概括

脆弱X智障1 (FMR1) 基因相互作用与DISC1影响突触发育. 丢失dfmr1抑制了DISC1诱导的突触结节的形成,并改变了受体表达,揭示了在谷氨基质突触发育中的共享机制.

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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