多生物组分析识别出不同的肠道微生物特征及其在性结肠炎和克罗恩病中的交叉声
Shintaro Akiyama1, Suguru Nishijima2, Yasushi Kojima3
1Department of Gastroenterology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan.
Nature communications
|November 28, 2024
概括
肠道的微生物群.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 传染病 传染病 传染病 传染病
背景情况:
- 肠道微生物组在性结肠炎 (UC) 和克罗恩病 (CD) 等炎症性肠道疾病 (IBD) 中的作用是复杂的,涉及多个王国.
- 以前的研究还没有完全研究IBD患者肠道中的细菌,真菌和病毒之间的相互作用.
研究的目的:
- 在UC和CD患者中全面描述多王国肠道微生物群.
- 确定与IBD相关的特定微生物特征及其相互作用.
- 通过多样化的国际队列验证发现.
主要方法:
- 从日本IBD患者和健康对照的便样本的枪式转基因组测序.
- 对细菌种类,基因功能,抗菌基因,菌体和真菌的分析.
- 使用来自美国,西班牙,荷兰和中国的外部元基因组数据集进行验证.
主要成果:
- 丰富了Enterococcus faecium和Bifidobacterium spp.的生长方式 在UC和CD中.
- 在CD中的大肠杆菌缩,与抗生素耐药性和毒性因素相关.
- 与细菌组转移相关的病毒组变化,包括致病性菌体.
- 丰富了Saccharomyces paradoxus (UC) 和Saccharomyces cerevisiae (CD) 的作用.
- 在CD中Saccharomyces cerevisiae,大肠杆菌和短链脂肪酸 (SCFA) 生产细菌之间的负相关性.
- 多个王国微生物群的跨文化相似性,IBD中的微生物群特征和相互作用.
结论:
- 在UC和CD中的肠道微生物组失生症涉及细菌,菌体和真菌的复杂相互作用.
- 特定的微生物种群及其相互作用,如大肠杆菌和Saccharomyces cerevisiae与SCFA生产者,与IBD有关.
- 针对这些多王国相互作用网络的治疗策略可能为IBD治疗提供了希望.
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
138
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
138
Inflammatory Bowel Disease II: Crohn's Disease
185
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
185
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
317
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
317
Chronic Bowel Disorders: Introduction
388
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
388


