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Updated: Jun 6, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Published on: December 11, 2017

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YY1下调是对分子向药物的治疗反应的基础

Shichao Zhou1,2, Jingyu Zang3, Mei-Chun Cai1

  • 1State Key Laboratory of Systems Medicine for Cancer, Department of Thoracic Surgery, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cell death & disease
|November 28, 2024
PubMed
概括

转录因子阴阳1 (YY1) 通过调节细胞循环和自来驱动癌症药物耐药性. 抑制YY1增强了向治疗的有效性,并防止了肺癌的耐药性.

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