西丁是多功能生物对等的硫化捐赠者
Wenyuan Xu1, Cheng Tang1, Ruohan Zhao1
1State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Inter-disciplinary Research Center, Nanjing University, Nanjing, 210023, China.
Nature communications
|November 28, 2024
概括
新的 sydnothiones 作为生物对称的硫化 (H2S) 捐赠者,使其能够控制释放潜在的治疗应用. 这些H2S捐赠体在改善细胞活力和抗化学疗法药物方面表现有前途.
科学领域:
- 化学生物学 化学生物学
- 药用化学 医学化学
- 生物化学 生物化学
背景情况:
- 硫化 (H2S) 是一种至关重要的内源气体传递物.
- 开发生物对等的H2S捐赠体仍然是一个挑战.
- 现有的生物对角系统缺乏对H2S释放的精确控制.
研究的目的:
- 设计和合成新的生物对等的H2S捐赠体,称为 sydnothiones.
- 为了研究使用 sydnothiones H2S 的受控和有针对性的释放.
- 探索从sydnothiones释放的H2S在减轻药物诱导的细胞毒性的治疗潜力.
主要方法:
- 密度函数理论 (DFT) 对 sydnothione 设计的计算.
- 悉诺和压力基因 (DIBAC) 之间的生物对等循环添加反应.
- 评估与其他生物对对的反应正角性 (四素-Nor,四素-MOHO).
- 评估H2S对H9c2细胞中多克索鲁比诱导的细胞毒性的影响.
主要成果:
- Sydnothiones成功地被设计和合成为H2S捐赠者.
- 实现了可控制,可调节和针对线粒体的H2S释放.
- 悉诺-DIBAC反应表明与其他生物对角系统的正交.
- 使用 sydnothione 和 DIBAC 的预处理显著增强了 H9c2 细胞对抗多克索鲁比的活力.
结论:
- Sydnothiones代表了一类新的生物对等的H2S捐赠者.
- 这个平台允许选择性H2S释放和潜在的治疗干预.
- 这项研究强调了H2S对多克索鲁比诱导的细胞毒性的保护作用.
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