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默认模式网络和背部注意网络连接的变化作为腰椎椎间盘的脊柱操纵疗法的神经标记

Xing-Chen Zhou^1,2,3, Shuang Wu^1,2, Kai-Zheng Wang^1,2,3

¹The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.

Scientific reports

|November 28, 2024

概括

脊柱操纵疗法 (SMT) 通过调节大脑网络,有效地减少腰椎间盘 (LDH) 患者的疼痛. 关键的神经生物标志物,包括默认模式和背部注意网络,表明SMT.

科学领域:

神经科学是一个神经科学.
整形外科整形外科整形外科
康复医学康复医学康复医学

背景情况:

腰椎间盘 (LDH) 是腰部疼痛的一个常见原因.
脊柱操纵疗法 (SMT) 在缓解LDH疼痛方面表现有前途,可能通过大脑功能调节.
识别神经生物标志物对于理解SMT疗效至关重要.

研究的目的:

在LDH患者中调查SMT后与疼痛缓解相关的神经生物标志物.
为了比较SMT,假治疗和健康对照之间的大脑网络变化.
为了将大脑活动与临床疼痛得分相关联.

主要方法:

功能磁共振成像 (fMRI) 用于评估59名LDH患者 (SMT与假) 和28名健康对照者的大脑连接.
使用视觉模拟尺度 (VAS) 和日本整形医学协会 (JOA) 尺度进行治疗前后的临床评估.
图形理论对大脑网络属性的分析.

主要成果:

在VAS和JOA分数上,SMT组显示出显著的改善;假组仅在VAS上有所改善.
在LDH患者和对照人群之间观察到明显的脑网络连接差异.
在SMT组中,功能连接的增强,特别是在右角旋转和左中轨道旋转之间,与临床改善相关.
在慢性疼痛中,感觉运动和突出网络被激活;默认模式和背部注意网络可能表明SMT的有效性.

结论:

SMT为LDH患者提供了显著的疼痛缓解,与特定的大脑网络调制有关.
功能连接的改变,特别是涉及直角,是SMT治疗成功的生物标志物.
默认模式和背部注意网络显示出作为SMT在LDH疼痛管理中的有效性关键神经生物标志物的潜力.

关键词:

功能性磁共振成像技术功能性磁共振成像技术图形的属性图形的属性腰椎椎间盘的发生脊柱操纵疗法是一种脊柱操纵疗法.

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