在肥胖和非肥胖的高血压患者中解读脂肪肝-高血压关系:从一项队列研究的见解
Chuanli Yu1,2,3, Congcong Ding1,2,3, Chao Yu4,2,3
1Department of Cardiology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Scientific reports
|November 28, 2024
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 在高血压患者中增加了高尿血症的风险. 这种关联在正常BMI和非中心肥胖症的个体中尤为强烈,突出显示MAFLD是独立的危险因素.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和血清尿酸水平升高与心血管和脑血管疾病有关.
- MAFLD和血清尿酸之间的直接因果关系尚未得到充分证实.
研究的目的:
- 研究由脂肪肝指数 (FLI) 定义的MAFLD与在没有先前存在的高尿路血症的患者中新发型的高尿路血症的发展之间的关联.
- 探索潜在的非线性关联,并确定更高风险的特定子组.
主要方法:
- 分析了3417名没有高尿血症的患者队列,MAFLD被定义为FLI≥30.
- 多变量考克斯回归,受限立方线和值和效应分析在4年的随访期内被采用.
- 小组分析的重点是体重指数和中心肥胖状态.
主要成果:
- 较高的FLI得分与新发性高尿路血的风险增加有显著的关联.
- 与最低FLI四分位数 (Q1) 相比,最高四分位数 (Q4) 显示风险增加了56% (HR: 1.56).
- 观察到显著的非线性关联,尤其是正常BMI (<24 kg/m2) 和非中心肥胖症患者的风险增加.
结论:
- 在高血压患者中,MAFLD是发展高尿血的独立危险因素.
- 这种风险在高血压个体中被放大,其体重指数正常,肥胖程度非中心.
- 这些发现表明MAFLD在尿酸代谢中的作用及其对心血管健康的影响.
相关概念视频
01:24Obesity
379
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
379
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
78
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
78
01:29Cholesterol: Significance and Regulation
510
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
510