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在ASD的环境模型中,mTOR-FMRP通路和突触可塑性的失调

Muna L Hilal1,2, Eleonora Rosina1,3, Giorgia Pedini3

  • 1Department of Fundamental Neurosciences, University of Lausanne, 1005, Lausanne, Switzerland.

Molecular psychiatry
|November 28, 2024
PubMed
概括

怀孕期间母亲的免疫激活可以导致后代的自闭症类行为. FMR1基因突变并没有恶化这些行为,这表明mGluR1/5-mTOR途径是自闭症谱系障碍发展的关键.

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