试点级喷雾干燥机和实验室级喷雾干燥机之间的比较:结构,粉末特性和直接压缩的应用
Zhe Li1, Wanghai Peng1, Fucai Chen1
1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang, 330004, People's Republic of China.
AAPS PharmSciTech
|November 28, 2024
概括
使用喷雾干燥的颗粒设计增强了直接压缩粉末的性能. 观察到流动性和可分片性的规模依赖差异,指导药物开发的设备选择.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 由于其简单性和成本效益,直接压缩是平板电脑制造的首选方法.
- 实现最佳的粉末特性,如流动性和紧缩性,对于成功的直接紧缩至关重要.
- 粒子工程提供了一种有前途的方法来增强这些粉末特性.
研究的目的:
- 研究使用喷雾干燥的颗粒设计对直接压缩粉末的性能的影响.
- 评估不同尺度的喷雾干燥 (实验室与试点尺度) 对粉末特性的影响.
- 探索基甲基纤维素,聚烯,二碳酸和二碳酸在颗粒设计中的使用.
主要方法:
- 使用实验室和试点规模的喷雾干燥机制备复合材料和多孔颗粒.
- 包括基基甲基纤维素和聚烯利作为修饰剂.
- 使用二碳酸和二碳酸作为孔形成剂.
主要成果:
- 设计的粒子结构显著改善了粉末的流动性,可平板性和分解性.
- 实验室规模的喷雾干燥产生了具有优越可颗粒性的复合颗粒.
- 试验规模的喷雾干燥产生了具有增强流动性的复合颗粒.
结论:
- 根据使用的喷雾干燥规模,粉末特性存在显著差异.
- 精心选择喷雾干燥设备和实验设计对于优化粉末性能至关重要.
- 这种粒子设计策略具有开发天然植物性平板电脑的潜力.
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