肠道生理学和环境解释了人类肠道微生物组合和新陈代谢的变化
Nicola Procházková1, Martin F Laursen2, Giorgia La Barbera1
1Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.
Nature microbiology
|November 28, 2024
概括
人的肠道微生物群每天都在变化,受肠道生理学和环境的影响. 过境时间和pH显著影响微生物代谢和健康成年人的代谢物产生.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 人的肠道微生物组高度个性化,但肠道生理学和环境在其变异中的作用尚未得到充分理解.
- 了解这些因素对于破译肠道微生物组的个性至关重要.
研究的目的:
- 研究肠道生理因素 (过境时间,pH) 和环境变化对人类肠道微生物组合和新陈代谢的影响.
- 为了确定特定代谢物和肠道传输/pH参数之间的关联.
主要方法:
- 一个观察性多omics试验,涉及61名健康成年人超过9天.
- 在50名参与者中使用无线运动囊评估每日肠道环境因素,全肠和细分肠道过境时间和pH值.
- 对微生物组合,新陈代谢和代谢物与生理参数的相关性进行分析.
主要成果:
- 观察到肠道微生物组和新陈代谢的每日大幅波动.
- 个体内变化与便水分和便pH值的变化有关.
- 个体间的变化与全肠和细分过渡时间和pH相关.
- 微生物碳水化合物发酵代谢物与肠道通路时间和pH负相关,而蛋白质代谢物和甲显示出正相关性.
- 分段过渡时间/pH与咖啡,饮食,宿主和微生物衍生代谢物相关.
结论:
- 肠道生理学和环境是人类肠道微生物组个性的关键决定因素.
- 过境时间和pH值显著调节微生物代谢和代谢物概况.
- 这项研究提供了关于宿主,肠道环境和微生物群之间的动态相互作用的见解.
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