托及其代谢物与危急疾病的老年患者 Delirium 的可能相互作用
Korhan Kollu1, Huseyin Kurku2, Ali Unlu3
1Division of Intensive Care Medicine, Department of Internal Medicine, Konya City Hospital, University of Health Sciences Türkiye, Akabe, Adana Çevre Yolu Cd. No: 135/1, 42020, Karatay, Konya, Turkey. korhankollu@gmail.com.
危急病的老年患者的痴呆症可以通过早期测量二及其代谢物来预测. 较高的金氨酸/氨酸和氨酸/氨酸比率表明 Delirium 的风险增加.
科学领域:
- 生物化学 生物化学
- 关键护理医学 关键护理医学
- 老年病的医生 老年病的医生
背景情况:
- 痴呆症是重病老年患者的常见并发症,与不良结果有关.
- 在狂妄症的病原发生中,托芬代谢的作用仍然不完全理解.
研究的目的:
- 在重症老年患者中研究妄和酸盐及其代谢物之间的关系.
- 评估这些生物标志物在预测狂妄风险方面的潜力.
主要方法:
- 这是一项前性观察性研究,对120名年龄在60岁以上的患者进行了观察,这些患者被录入内科ICU.
- 在基线和24小时后随访时进行 Delirium 评估.
- 测量血清三位素 (TRP) 和其代谢物:金氨酸 (KYN),金氨酸 (KYNA),金氨酸 (QA),3-氧金氨酸 (3-HK) 和3-氧氨酸 (3HAA).
主要成果:
- 患有妄想症的患者的中位数年龄和CCI得分显著更高.
- 在痴呆症患者中观察到TRP水平的边界显著下降 (P=0.056).
- 在痴呆症患者中发现显著更高的KYN/TRP (P<0.001) 和QA/TRP (P=0.016) 比率.
- KYN/TRP比率 (AUC:0.704) 和QA/TRP比率 (AUC:0.627) 显示出的预测值.
结论:
- 在ICU入院后24小时内测量的托芬及其代谢物可以预测老年患者的痴呆风险.
- KYN/TRP和QA/TRP比率是识别高风险个体的潜在生物标志物.
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