卡尼丁代谢物作为男性肉类的潜在循环生物标志物
Je Hyun Seo1, Jung-Min Koh2, Han Jin Cho3
1Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea.
Endocrinology and metabolism (Seoul, Korea)
|November 28, 2024
概括
卡尼丁 (CN) 代谢物,特别是C5-CN,显示出作为男性肉类的循环生物标志物具有前途. 较低的C5-CN水平与肌肉质量和力量的减少有关,有助于早期检测.
科学领域:
- 老年学是指老年学的学科.
- 代谢学 代谢学 代谢学
- 肌肉生理学 肌肉生理学
背景情况:
- 麻症是一种与代谢功能障碍相关的复杂疾病,为识别代谢物生物标志物提供了机会.
- 对于骨肌肉的能量代谢至关重要的卡尼丁 (CN) 是肉症的潜在候选生物标志物.
- 这项研究调查了卡尼代谢物作为沙科白的潜在生物标志物.
研究的目的:
- 评估卡尼丁 (CN) 代谢物作为男性肉类的潜在循环生物标志物.
- 为了确定CN代谢物和萨科佩尼亚状态,肌肉质量和手握强度之间的关联.
- 评估CN代谢物的诊断和预测价值,以识别肉症.
主要方法:
- 使用动物模型和肌肉细胞研究确定了卡尼丁代谢物.
- 在两个人类队列中评估了CN代谢物和肉类之间的关联:发现队列 (72例,72对照) 和验证队列 (21例,47对照).
- 统计分析包括评估与肉类病状况,手握强度和骨肌肉质量的关联,并计算接收器操作特征曲线 (AUROC) 下的面积.
主要成果:
- 与对照组相比,在患有肉症的男性中,血C5-卡尼丁 (C5-CN) 水平明显较低 (P=0.005).
- C5-CN水平与骨肌肉质量相关 (P=0.003) 并倾向于与手握强度相关 (P=0.098).
- 在发现 (0.646到0.727) 和验证 (0.563到0.712) 队列中,添加到手握强度时,一个包含C5-CN水平的CN得分提高了对肉症检测的AUROC.
结论:
- C5-卡尼丁 (C5-CN) 是男性肉类的潜在循环生物标志物,表明肌肉质量低.
- 结合C5-CN水平与手握强度的结合,提高了对肉类症的鉴定准确度.
- 需要进一步的研究来验证这些发现,并探索在肉症中更广泛的代谢变化.
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