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来自PRDM9的aKRAB的多次损失与远距离特异性的内核大小分布一致

Ann-Christin Zinner¹, Lars Martin Jakt²

¹Faculty of Biosciences and Aquaculture, Nord University, Universitetsalléen 11, Bodø, 8026, Norway.

|November 28, 2024

概括

内子大小的远距离分布 (TD) 独立地进化了多次,与PRDM9基因的aKRAB域的丢失有关. 这表明基因组进化可以作为遗传变化的副产品发生,而不仅仅是选择.

科学领域:

基因组学就是基因组学.
进化生物学进化生物学
分子生物学分子生物学

背景情况:

主要RNA转录中的非编码序列 - - 内子 - - 通常被删除.
脊椎动物内部尺寸分布通常是一致的,除了在大多数鱼类中发现的独特的"远距离分布" (TD).
TD的进化起源和驱动机制 (适应性与非适应性) 仍然不清楚.

研究的目的:

为了研究远距离分布 (TD) 在内部尺寸的独立演变.
确定PRDM9基因,特别是其aKRAB域在TD出现中的作用.
了解重组,基因组架构和内部尺寸进化之间的关系.

主要方法:

分析了各种teleost基因组的内子大小分布.
在注释基因组中识别了PRDM9的正义基因.
扫描了1193个teleost组件,以检测PRDM9.9中的aKRAB域是否存在.

主要成果:

在teleosts中,TD至少在6次独立演变.
TD的出现与PRDM9基因中aKRAB域的丢失有很强的相关性.
大多数teleosts拥有一个分散的PRDM9形式缺乏aKRAB域,而祖先形式是罕见的;在缺乏aKRAB的血统中,TD很普遍.

结论:

在PRDM9中失去aKRAB域可能改变了重组和结构变异热点.
TD似乎是这些与PRDM9相关的基因组变化的非适应性副作用.
这项研究将内子大小和基因组架构的演变与重组机制的变化联系起来,独立于直接选择.

关键词:

基因组的演变基因组的演变内部长度内部长度介质性再组合是介质性的再组合.电视节目电视节目电视节目

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